Complete List of OTC (and Prescription) Drugs To Get High

If you’re interested in using any prescription or over-the-counter drug for an “off-label” or non-medical purpose, always do your research before taking it.

Using any drug without careful consideration can cause unpleasant side effects, major health problems, or even death if you avoid studying up on the effects first.

Can You Get High on Ativan? Don’t Try It!

Ativan (generic name: Lorazepam), a Benzodiazepine used to treat anxiety and seizures, has been classified as one of the WHO’s Most Essential Medicines, meaning it is a safe, essential medicine when used as prescribed.

If you want to use it recreationally, you’ll most likely feel relaxed, though some users have experienced hallucinations or the feeling of being drunk. Ativan has several unsavory uses; one of them is as a “date rape” drug.

Ativan offers minimal effect, and you can better achieve any recreational goals with other substances.

Verdict: Don’t Try It

Can You Get High on Adderall? Yes.

One of the most popular ADHD medications in the U.S, doctors also prescribe Adderall for depression and narcolepsy. Taken by 5 million patients, it’s among the most abused prescription drugs, and highly available on the black market.

A Schedule IIN Drug, it has a high potential for abuse, according to the DEA. Many students use it as a study aid for increased concentration. It also has a strong euphoric effect on many users.

Use Adderall responsibly, for studying or increased concentration and don’t go overboard with the dosage.

Verdict: Yes

Can You Get High on Baclofen? Yes.

The muscle relaxer Baclofen used to treat stiffness and spasms from multiple sclerosis, can also be used off-label for anxiety. Recreational users are few and far between, but they do laud the drug for its mild euphoria and relaxing effects.

One of our contributors took 20 milligrams 3 times a day and experienced a chill-out feeling”, so Baclofen’s a good option if you want to relax.

Baclofen has many minor side effects like weakness and drowsiness. Withdrawal from the drug can be painful, and involve hallucinations and delirium.

To get high on Baclofen, use in small doses and restrict the number of times you use it to stay safe.

Verdict: Yes

Can You Get High on Benadryl? Yes.

You’ve heard of Benadryl and may have used it for an allergy. It’s an antihistamine and a brand name for the drug Diphenhydramine.

You can get Benadryl over the counter at any drug store or grocery store.

Recreational users over on Reddit agree taking too much (700-900 milligrams) can give you a bad trip with some intense hallucinations. In lower doses, it can help you relax.

Stick to lower doses if taking Benadryl for recreation, and avoid high doses and the resulting bad trips.

Verdict: Yes

Can You Get High on Benzonatate? No.

The cough suppressant Benzonatate, available in yellow and orange capsules, treats coughs from the common cold. Some people believe you can get high from taking a certain amount of Benzonatate. The high may cause drowsiness and hallucinations.

Users on Reddit advise against using Benzonatate for recreational purposes. You won’t feel anything pleasant, and may just get a headache if you take a bigger-than-average dose of this drug. It has some pretty serious side effects, including cardiac arrest and coma.

Skip Benzonatate for recreational purposes. Use it only as a cough suppressant.

Verdict: No

Can You Get High on Citalopram? No.

The antidepressant Citalopram, sold under brand name Celexa, treats depression. Prescribed as a SSRI inhibitor, it creates a slow, calming effect, similar to Xanax.

This slow-release drug takes weeks to work, so it’s not a good choice for recreational use. The few people who’ve used it recreationally have experienced calming effects. The side effects of Citalopram can be severe, including suicidal thoughts and visual hallucinations.

If you do decide to use Citalopram, you’ll feel a mild drowsiness, but remember to take a small dose.

Verdict: No

Can You Get High on Cyclobenzaprine? Yes.

A muscle relaxer used in conjunction with physiotherapy for injuries and the resulting physical pain, Cyclobenzaprine offers tranquilizing effects according to some recreational users. There’s little chance of abuse or addiction, like Benzodiazepine.

Reddit users credit it with making them more relaxed, though not necessarily high in the conventional sense. Some users take cyclobenzaprine along with marijuana or other substances to achieve a more relaxed state.

This drug produces results for some recreational users. If you want to try it, start with a small dose and slowly raise it if it works for you.

Verdict: Yes

Can You Get High on Cymbalta? No.

Cymbalta, the brand name for the chemical Duloxetine, is used to treat anxiety, depression and muscle pain. Classified as an SNRI, it works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. Reddit users give it thumbs down as a recreational mood-booster, with remarks including “it made me really sick, almost to the point of throwing up.”

It may not make you sick, but it will stunt your appetite, which can result in significant weight loss if you use it long-term. Other side effects include loss of sex drive. Cymbalta does put you in a slightly cheerier mood, but that’s the drug’s only recreational selling point.

Verdict: No

Can You Get High on Dicyclomine? No.

Used to treat irritable bowel syndrome and stomach cramps, Dicyclomine may seem like an unlikely entry as a recreational drug. Sold under brand names including Bentyl, Dibent and Dilomin, at least one Reddit user reports experiencing “trippy” hallucinations while on the drug.

Dicyclomine is unreliable for IBS and causes dry mouth, anxiety, depression and headaches. It can interact with any MAOIs, antihistamines, and benzodiazepines you’re taking. You’ll be better off avoiding Dicyclomine for recreational purposes since it has the potential for some pretty unpleasant side effects and little chance of producing a high for most people.

Verdict: No

Can You Get High on Escitalopram? Maybe.

You probably haven’t heard this unpronounceable name but you know of its brand name, the anti-depressant Lexapro. A SSRI sold in pills from 5 to 20 milligrams; it may affect you differently than other users. On Reddit, user reaction range from feeling “amped up in a good way” to “extreme apathy.”

Similar to Citalopram, this drug can impair your sex drive, and cause bouts of anger. On the plus side, it boosts mood and motivation. Like other SSRIs, Escitalopram’s effects can be unpredictable, so try it in small doses and add more if it works for you.

Verdict: Maybe

Can You Get High on Flexeril? Yes.

Flexeril’s a brand name for the muscle relaxer Cyclobenzaprine, commonly used to treat pain and injuries. Recreational users like it because it blocks pain signals to the brain. Used on its own, Flexeril relaxes your muscles and gives you a pleasant high.

According to one Reddit user, “I’ve had good luck with 20mg and three beers to potentate the effects, add in a little weed, and the euphoria comes on strong..” Serious side effects include mood swings and irregular heartbeats.

When used as a recreational drug, Flexeril may give you a chill feeling. Try a small amount and slowly add more if the initial dose works. Take care when using alcohol, MOAIs, or other drugs while you use Flexeril, or better yet, use it without other compounds.

Verdict: Yes

Can You Get High on Hydrocodone? Yes.

An opioid painkiller, you may know Hydrocodone by the brand names Norco, Lortab or Vicodin. It’s prescribed to treat moderate to severe pain but has definite potential for abuse and addiction. Classified as a Schedule II Drug in the U.S., it’s widely available on the black market.

You may experience a pleasant euphoria after taking a 30-35mg dose of the drug or need to have a few alcoholic drinks before feeling any effect. Sold in pill or syrup form, Hydrocodone’s a potent “narcotic analgesic,” with side effects including vomiting, nausea, anxiety and mood swings. It can produce a nice high but use it occasionally to avoid side effects and abuse.

Verdict: Yes

Can You Get High on Kava Kava? Yes.

Kava Kava, made from a tropical flora, has been used as an anesthetic and sedative for centuries. The active ingredients in this herb, kavalactones, offer pain-relieving properties. Kava Kava’s also produced as a beverage with effects similar to alcohol.

Touted for its calming properties, one of our contributors reported feeling sedated, but still in control one hour after taking 1250 milligrams (five capsules) of Kava Kava. After the effects wear off, you’ll probably want to take a nap.

There’s little evidence of addiction or overdose with Kava Kava. It may be toxic to the liver when taken in high quantity. As long as you buy Kava Kava from a reliable source and take it in small doses, you should be safe.

See Can You Get High on Kava Kava? for my experience with Kava Kava.

Verdict: Yes

Can You Get High on Klonopin? Yes.

A prescription drug originally developed to treat epileptic seizures, Klonopin is now used to relieve anxiety and panic disorders as well. Despite being classified as a Schedule IV drug with a low risk of abuse and addiction, many users have problems with Klonopin due to the severity of the withdrawal symptoms.

Reddit users have referred to the Klonopin high as being calm and pleasant, and our contributor experienced a “buzzed peacefulness.” Paranoia, aggression and depression are among the side effects.

Limit dosage and frequency if you decide to use Klonopin for recreational purposes. Monitor its interaction with alcohol, supplements, and other drugs.

Verdict: Yes

Can You Get High on Lamotrigine? Don’t Try It!

Lamotrigine, an anti-seizure drug, is also prescribed for bipolar disorder. Its mood-alerting properties make it a recreational drug of choice for some people. The medication comes in regular, extended release, chewable and dissolving tablets.

According to some clinical users, Lamotrigine can balance your moods, but you need to slowly ramp up the amount used, and avoid stopping and starting the drug. Taking to much too quickly can cause SJS, a fatal skin reaction.

Lamotrigine is rarely used as a recreational drug, and its potential mood-altering properties aren’t worth the side effects. Avoid this one.

Verdict: Don’t Try It

Can You Get High on Legion Supplements? Yes.

Legion Pulse, the best known of the Legion Supplements, is a pre-work powder used by bodybuilders and athletes. It supplies energy and increases endurance before a workout. The powder contains betaine, citrulline malate, beta-alanine, ornithine and other natural substances.

The recreational effect of Legion Pulse mimics caffeine for focus and endurance. It gives you a rush similar to Red Bull or other energy drinks. You may get the runs or feel jittery if you mix too much Legion Pulse into your drink, but that’s about it for negative effects
Use in moderation, and you’ll get more energy to focus on sports and other physical tasks.

Verdict: Yes

Can You Get High on Lexapro? Maybe.

Lexapro, one of the most-prescribed SSRIs, treats depression and generalized anxiety disorder.