CILTEP Review – Don’t Buy Until You Read This

Over the last year, much attention has surrounded a phenomenon known as long-term potentiation (abbreviated as LTP) which promises to bring new light to the nootropic universe.

It is a concept that describes our brains’ innate ability to encode new knowledge and behavior.

LTP works through the programming of nerve connections, which physically represent our thought patterns and in essence, whatever is stored inside of our heads.

When I first held the small blue container from NaturalStacks, I had a feeling that CILTEP would be a powerful supplement.

Could this serendipitously-discovered formula truly live up to all of the hype I’ve seen online?

This nootropic has long-term potential

Throughout my years of experimenting with nootropics, I have found it difficult to find substances that were both effective and consistent – staying beneficial in the long term. I had hoped this was all about to change.

Stacking CIPTEP – Who is it for?

The benefits of CILTEP are highly valuable to nootropic fanatics for a few reasons. Firstly, for the positive effects on memory it can have. Because long-term potentiation facilitates our ability to use and store new information, it can be a great adjunct to studying and otherwise learning (or practicing) new skills.

Another desirable effect is an amplification of the activity of neurotransmitters such as epinephrine, acetylcholine and dopamine. This results in a powerful improvement in cognition, as well as overall speed.

Some people might look at CILTEP as a way to improve athletic performance, because it also increases sensitivity to certain hormones. This could aid both workouts and recovery time by naturally altering the body’s chemistry.

What Does the Stack Contain?

An interesting part of the concept of the CILTEP stack is that you don’t need specific ingredients in order for it to be valid, nor for it to work. The functionality behind CILTEP occurs with the synergy of three pharmacological classes of chemicals – each with a factor that helps the next.

Increasing cAMP

Chiefly, the effects of CILTEP are created by increasing levels of cyclic adenosine monophosphate, or cAMP for short. cAMP is a molecule that performs the function of second messaging, which is the transmission of signals from the outside of a cell to parts within it.

For example, a receptor can affect the activity in a cell’s nucleus through a second-message molecule such as cAMP. Specifically, cAMP allows hormones such as adrenaline and glucagon to cause their effects on cells, as well as activating protein kinases. When you have more of it, neurotransmitters function more effectively because their signals on cells act more efficiently.

At the current time, there is only one common supplement that directly raises cAMP levels. It is forskolin, an Indian plant extract that is known for enhancing sensitivity to various substances. Forskolin can be found usually as capsules from health food or supplement vendors – it isn’t hard to find.

Inhibiting PDE4

Directly increasing cAMP is perhaps the most limited part of the flexibility of the CILTEP formula, because usually forskolin is used.

However, the most significant factor in increasing cAMP comes from inhibiting PDE4, an enzyme responsible for its breakdown. Since there are many choices of chemicals that inhibit PDE4, it is a very flexible component in the stack.’

One option is rolipram, which is a relatively unheard of racetam drug that has been sought specifically as a PDE4 inhibitor. In practice. it isn’t often used because of its side-effect profile, which includes nausea and vomiting.

More commonly, the PDE4 inhibitor used for CILTEP comes from artichoke extract in the form of luteolin. This chemical acts as an antioxidant and immunity booster in addition to its inhibitory effects.

Luteolin doesn’t have the significant adverse effect profile like with rolipram, and since artichoke extract is a common supplement it is easily acquired.

Boosting Dopamine

A way to further boost the effects of cAMP from this stack is by adding a compound to naturally increase dopamine levels. Not only will you feel an intensified dopamine response due to the other ingredients, but stimulating the correct receptors will release extra cAMP. This is harder than one thinks, however.

Activating the D2 receptor can potentially reduce cAMP levels, while the D1 receptor increases them. The substances that are more likely to help D1 act indirectly, via the NMDA receptor.

This includes most of the racetams and ampakines such as sunifiram. It also helps to take supplements that support natural dopamine production (such as tyrosine or phenylalanine) to ensure that receptors are able to be activated.

Sources & Side Effects

As noted above, the materials needed for CILTEP are easily found. They can be picked up in a shop or ordered online either as capsules or bulk powder.

There are no standard dosages for each part of the stack, but it is recommended to take one standard dose of each ingredient to attain the CILTEP effect. It can take up to a week to start feeling its effects such as an altered mood.

Side effects are minimal, as it is generally considered safe to moderately increase cAMP levels.

However, PDE4 inhibitors are well known to cause nausea when taken in high amounts – more than the standard dosage. With rolipram, this is seen even at the regular dose. So as long as you are careful with amount, there should be no problems.

A Week Using the CILTEP Stack

Due to the realized importance of this system, many users of nootropics (especially from Longecity, an online forum dedicated to the cognitive improvement and life extension) have researched and developed what is called the CILTEP stack.

This small but complex combination of supplements has been sought to induce and take advantage of LTP through a directly-controllable means. CILTEP stands for “Chemically-induced long term potentiation”, with the ‘E’ often being ignored in the mainstream. However, it would appear that it stands for “enhanced” when properly using the acronym.

Note: if you’d like to try CILTEP please sign up to my newsletter from the homepage to find out how to get one bottle for free

Day 1

Since I received my package from the dormitory mailroom at around noontime, I was already fairly far into my day. On the label for CILTEP, it recommends taking two to three capsules in the morning upon waking, or on an empty stomach.

Grudgingly, I decided I had to wait until my stomach emptied itself, so I wouldn’t be wasting the potency of the formula. After going to the gym with a friend, I decided to pop three capsules before showering; not knowing what cognitive changes awaited me.

I didn’t feel much immediately, possibly due to the fact that my stomach wasn’t completely empty and that perhaps the effects arrived over time. Knowing that the CILTEP stack was designed to enhance learning ability, I also assumed that that best way to judge it was by studying. The rest of that day, I did notice a subtle mood lift and increased sociability.

Day 2

In a way, I count this as my first day because I followed directions precisely by taking CILTEP upon waking. As usual, I took my 200 milligram tablet of SAM-e, and put three CILTEP capsules down the hatch. The past couple days, I had been thinking about the need for co-administering B-vitamins with SAM-e, so I swallowed a tiny bit of an energy shot as an attempt to meet this quota.

Within about twenty minutes, all I could say was “WHOA!”

keanu woah face

I have heard stories about CILTEP potentiating caffeine, but I had no idea that a few milliliters of energy shot would feel this strong! I walked to work (an on-campus job) with my goals set in mind and the energy to perform at my best.

Three hours of programming and web administration seemed to go by in a blur of productivity. Honestly, I was so focused on the task at hand that I hardly remembered I had taken the CILTEP!

After work, I went to my only class that day – an oral and written communications course in which I had to regularly perform speeches. I felt like I was able to better understand what the professor was saying, and I had a brilliant idea for the topic of my next speech, which I quickly wrote down on some paper.

The rest of the day, I powered through a section of my logic design project that involved many pages of Boolean algebra and playing around with microchip arrangement. Somewhere in the middle of that, I remember telling my dad on the phone how amazing CILTEP was. I will say that around 9pm or so, I crashed.

I could tell that the extra productivity had its toll, and I needed sleep badly. Oddly enough, I couldn’t get myself to sleep for a couple more hours, since I was still focused.

There was one interesting effect I experienced in the afternoon – I was feeling a touch of megalomania, like I could control the world. This was accompanied by a mild stomach ache and a huge feeling of intensity that caused me to text my friend “I don’t want to be God anymore.”