What are the most powerful nootropics?
How do we define power? How we define strength?
When it comes to nootropics, “powerful” means effective.
Out of thousands of legal nootropics on the market today, there is just a handful that I can count on to deliver, every time.
Here are the top 13 strongest nootropics on earth:
- Selegiline (L-Deprenyl)
- Bacopa monnieri
- Fish Oil
- Vitamin D3
- Lion’s mane
- Modafinil (not legal in most incountries)
- Coconut Oil
In this article, I lay out the benefits, side effects, and ideal dosages of each to get the maximum effect. I also share my own personal experiences with each nootropic.
A new generation of nootropics? Noopept is a nootropic peptide developed and prescribed in Russia.
It is derived from the racetam family of compounds and has a common mechanism of action; but is purported to be up to 1000 times more potent than piracetam – being the most popular and most researched nootropic of our generation.
Part of the Ampakine sub-class, the Racetam family of nootropics work in part by binding to glutamate receptors. This augments the neurotransmitter glutamate and enables the more fluent encoding of memory and hence significantly boosts learning capacity.
However, the Racetam family have only weak to moderate AMPA modulation, and possess many different mechanisms of action. Noopept can lead to:
- Increased creativity
- Improved mood
- Reduced stress
- Augmented levels of focus and motivation
- Higher levels of verbal acuity (I particularly notice this)
- Higher self-esteem (as everything seems easier)
The majority of researchers recommend Noopept be taken sublingually, and it is my opinion that this advice should be adhered to (I have experienced the most positive effects).
Dosing varies anywhere from 10mg-30mg three times daily, I would strongly advise against mega-dosing as several negative side effects can occur (irritation, sedation, emotional numbness).
You may wish to have a chaser at the ready as this chemical tastes like paracetamol made by the devil.
I have taken Noopept extensively and would highly recommend it as a nootropic compound. With minimal dosing I experience improved creativity, confidence and verbal acuity.
Negatively I am quite confident that Noopept reduces my libido and without an obvious mechanism for this effect, more study is warranted to quantify its safety.
This substance is not piracetam, and has not been rigorously tested in humans. If you don’t mind being a guinea pig, you won’t mind noopept. Enjoy.
Synthesized in the form of Piracetam in 1964 by the Belgian pharmaceutical company UCB led by Dr. Corneliu E. Giurge,; the Racetam family is a class of nootropics which shares a dpyrrolidone nucleus and possess an affinity with the inhibitory neurotransmitter GABA (Gamma Amino Butyric Acid).
Part of the Ampakine chemical sub-class, the Racetam family of nootropics work in part by allosterically binding to AMPA-type glutamate receptors. This augments the neurotransmitter glutamate and enables the more fluent encoding of memory and hence significantly boosts learning capacity.
However, unlike more specific Ampakines, the Racetam family have only weak to moderate AMPA modulation, and possess many different mechanisms of action, these include but are not limited to:
- Improved function of the neurotransmitter acetylcholine via muscarinic cholinergic (ACh) receptors, indicated in memory functionality.
- Increased cell membrane permeability
- Modulation of ion flux and increased neuron excitability
- Increased blood flow and oxygen consumption in the brain.
- Improved mitochondrial membrane potential and ATP production
- Improved glucose metabolism in most cortical regions of the brain.
Although Piracetam is most famous and studied of the Racetam family, several newer and potentially superior Racetams now exist on the market.
These Racetams are increasingly popular due to their superior molecular composition and bioavailability and also due to the FDA’s attempt to halt Piracetam production in the USA. A list of these below:
Each analog possesses its own unique action and I encourage any that are interested to investigate these differences before choosing the right Racetam for you.
Other Racetams exist but, the three above are commonly available and are relatively affordable.
I avoid buying Racetams in pill form, instead buying bulk powders due to their cost effectiveness.
Of the aforementioned Racetams, the most popular is Aniracetam, Many nootropics users come to find that they are “Racetam sensitive” and this lipid soluble Racetam gives me significant/non-placebo effects on as small a dose as 200mg 3x daily.
I experience lowered anxiety, increased creativity and verbal acuity, and at 30$ for 50g, that’s 83.3 days of Aniracetam or, 2.5$ a week you can’t go wrong.
When taking either Pramiracetam or Aniracetam, don’t forget to take them with a fat source (they are both fat soluble); an effective co-supplement is a mercury filtered fish oil capsule, but more on that later. Oxiracetam is water soluble and goes down fine with a cup of water.
Don’t stress too much about how well each ‘racetam is absorbed because they are all 100% bioavailable. The fat co-supplements give a small added bonus.
Selegiline (L-Deprenyl), have you heard of it? should you be taking it? Buckle up and get ready to be more bored than a cat with no paws
Selegiline at normal doses is selective irreversible MAO-B inhibitor. MAO-B is an acronym for: Monoamine oxidase B, a protein enzyme located in the mitochondrial outer membrane.
It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.
In other words: Monoamine oxidase B catalyzes the break down (important for you folks) of the neuroactive amines dopamine and phenylethylamine.
Through this inhibition, less dopamine and phenylethylamine are deaminated, and thus brain-dopamine/phenylethylamine levels significantly increase, and oxidative stress (carcanogenic) is decreased
Here are a few of Selegiline’s benefits:
- Immune-system booster
- Protects DNA from oxidative stress by hydroxyl and peroxyl radical trapping
- Increases production of superoxide dismutase (an enzyme which hinders the production of free-radicals)
- Enhances drive and libido
- Increases cognitive performance in Alzheimer’s patients and some healthy indi