Nootropics & Sex: Can smart drugs help you in the bedroom?

Nootropics can be used for a variety of purposes based on their biochemical properties.

Usually, we think of them as being used for intellectual endeavors such as studying or getting ahead at work.  

However, many of them have been known for being useful for entertainment purposes as well.  

As humans, what is usually considered entertainment at the most primal and highest level?

Yes my friends, we are talking about sex.

Sex is often one of the last things we think about when we think about smart drugs. But it is quite possible that a person can combine intellectual biohacking with a superior experience in the bedroom.  

Many of the substances that we trust to enhance our productivity, or creativity, or even our logic can have a range of peripheral (or even central) effects on our bodies in regards to sexual performance and enjoyment.  

We’re certainly not talking about sexual-enhancement drugs like Viagra. Rather, are there nootropics that make you smarter and ignite your wild side?(as a side effect).

But aren’t nootropics NOT supposed to have side effects?

Nootropics in general are expected to be free of “side-effects”, however, this is a fairly blanket assumption because drugs simply affect a variety of systems within the body.  

We can ask that a nootropic drug should be free of negative side effects, such as headaches, nausea, and brain fog.  Such effects as say, sexual nerve stimulation and an increase in physical stamina could be considered bad side effects at some times, but for the purpose of this article we will say that we WANT such things to occur in addition to an increase in mental acuity.

Now that we have the question of mixing sex and nootropics covered, we need to take at some common sexually stimulating nootropics:

PDE Inhibitors

Perhaps a good place to start on the discussion of sex-enhancing nootropics is the world of Phosphodiesterase (PDE) inhibitors.  

This broad class of drugs generally works by preventing the body’s degradation of cyclic adenosine monophosphate (cAMP) or cyclic guanosine monophosphate (cGMP).  

These chemicals might be especially familiar to those of you who read our article on the CILTEP stack, which is a powerful nootropic formulation that aims to greatly enhance learning ability.  

Not a bad combo if you’re learning new tricks in bed with a partner.

The various PDE inhibitors, denoted by number, can cause varying effects across the human body, including ones of a notable sexual nature. As a demonstration of the ability of PDE inhibitors to help get a person rowdy, take the example of Viagra.

The “little blue pill”

Viagra is the brand name for sildenafil, is a well-known PDE5 inhibitor known for increasing the ability for a man to achieve an erection when suffering from erectile dysfunction.  

It works by inhibiting a cGMP-induced restriction of blood flow to the penis.  The drug appears to be reliable in users who need it, but it does not have a nootropic effect associated with it.

On the brain-enhancing side of PDE inhibitors, you specifically have PDE4 inhibitors.  Note that I said 4 not 5.

PDE4 inhibitors are also known for causing sexual stimulation, which is especially noteworthy in females.  

In a study done with rats, the synthetic PDE4 inhibitor rolipram was administered in an attempt to relieve depression and enhance the sex drive of a female subset.  

The result was a notable swelling of the clitoris – no doubt an effect that would enhance sensitivity and pleasure for the animal.  

In humans, however, rolipram is rarely used because of its emetic (vomiting) side effect– certainly not sexy to most people.[1

One example of a naturally-occurring (and non emetic) PDE4  inhibitor is Luteolin, which can be found in the extracts of artichoke as well as in trace amounts in celery and peanuts.  

Interestingly, the chemical quercetin, which is found in blueberries, has similar effects as luteolin.


Now we’re onto much more specific substances that aren’t as big of a pain to talk about as PDE inhibitors, phew!

Those of you who have dabbled in bodybuilding or other competitive athletic activities may be familiar with the name Yohimbine.  

Extracted from the bark of the Pausinystalia johimbe tree of west-central Africa, this substance is not only great for mental focus and motivation, but also well