LGD-4033 (Ligandrol) Review: Before and After Results [with Pictures]

In a previous post, I mentioned that I had started to experiment with SARMs after suffering back problems from a car accident. After a year of being laid up with vertebral fractures and compressed discs, I was pretty out of shape and needed to do something fast.

Since I was looking to build back the muscle I’d lost while shedding the pounds, I started using Andarine, a selective androgen receptor modulator (SARM) that had earned a lot of free press on online forums.

This research chemical had been touted as a natural supplement for treating muscle wasting and similar conditions, and bodybuilders were starting to use it to burn fat and promote lean muscle.

The results were impressive over time and, within a few months, I could see a real difference when I looked in the mirror. Even my basic mobility was much better. I could do stretches without throwing out my back.

But this got me thinking. Why limit myself to Andarine cycles when there are so many SARMs hitting the market? So, after doing a decent amount of research, I came across Ligandrol and decided to give it a try.

Below, I will go into more detail about my personal experience with LGD-4033 (Ligandrol), but first, let’s talk a bit about how it works and what you need to know before using it.

Important: What to Consider Before Buying Ligandrol

Before I continue: I got mine Ligandrol, aka LGD-4033, online from Proven Peptides.

But before you go there and grab a tincture, you should get an idea of its mechanism of action.

Ligandrol (also known as LGD-4033, or LGD, or LGD4033) is a selective androgen receptor modulator (SARM). SARM’s can bind to the androgen receptor of muscle and bone, and create similar results to oral steroids without the adverse side effects.

It was initially discovered to be effective in clinical trials that examined the effects of Ligandrol on patients with cancer. Researchers believed that the SARM could help to prevent symptoms of muscle wasting during cancer treatment, and they were correct.

Study participants who took Ligandrol saw increases in their muscle mass and overall better physical function.

While the drug hasn’t been approved for this specific purpose, it’s popular amongst bodybuilders in a bulking phase. Like steroids, Ligandrol mimics increased levels of testosterone in the body allowing you to build more muscle quickly.

However, unlike Ligandrol is well-tolerated, safe for most users, and does not affect prostate-specific antigens in the body.  Elevated levels of prostate specific antigen, like what you would see in someone using steroids, can put you at an increased risk of developing prostate cancer.

The fact that Ligandrol does not produce this dangerous side effect makes it a far safer choice than the anabolic alternatives.

How does Ligandrol work

LGD-4033 works by binding to the androgen receptor in your body. When it attaches to this receptor, LGD-4033 mingles with testosterone, influencing its capacity for gene production. This is what promotes muscle and bone growth.

Androgens are the hormones responsible for producing male characteristics in our physiology like the growth of facial hair, a deep voice, larger muscle mass, and lower levels of body fat. The best-known androgen is testosterone, but it’s not the only one the body produces.

The selective anabolic activity yields extra protein which contributes to muscle development. It’s sort of like steroids, working in much the same way but without all of the extreme side effects of ‘roids.

In fact, studies have shown it to be relatively free from side effects and it is said to be tolerated at all doses administered in at least one trial.

Consequently, it has been carefully considered for the treatment of several health conditions including osteoporosis, muscle wasting, certain types of cancer and sarcopenia (age-related loss of muscle mass and strength).

Researchers have also studied its effects on sex hormones and stair-climbing power, and their findings are very interesting. There was evidence of Ligandrol’s androgenic activity and substantial suppression of testosterone, HDL cholesterol levels and more.

This is all rather promising, but it’s important that you understand it is not without side effects in the long term. Some users have noted that Ligandrol can lower LH/FSH which affects the testicles and the production of testicular hormones. This can have an impact on adrenal hormones as well.

While Ligandrol is on the market primarily to treat age and illness related muscle-wasting diseases, there are applications for bodybuilders as well. Someone looking to gain significant muscle mass in a short period should research how to take LGD 4033 to achieve those results.

Is Ligandrol legal?

Ligandrol is a legal substance to buy and isn’t banned anywhere in the US. Outside of collegiate or professional athletes who are prohibited from taking performance enhancing drugs, anyone can Ligandrol for sale at a variety of retailers.

In 2015, the Florida Gators quarterback Will Grier received a one-year suspension for testing positive for a performance-enhancing substance.

Reports say that the drug in question was Ligandrol. While it is not a steroid, it is on the list of banned substances by the NCAA.

Grier says he began taking the supplement after a trip to a local nutrition store. He wanted to gain weight, and a clerk recommended the product to him. While reports say he put on a reported 40 pounds of muscle, Grier says the total increase in muscle was more like 22 pounds as a result of taking the supplement.

Unfortunately, he did not first check with his coaches and trainers to ensure that the supplement met NCAA standards before taking it.

LGD-4033 (Ligandrol) Pros and Cons

So now we know that Ligandrol has been proven to be effective as a treatment for several muscle-related ailments, even playing a vital role in overall body composition. But what are the other perks of taking Ligandrol?

It comes in pill, powder or liquid form, and can typically be taken safely in the short or long term to achieve mild gains.

This supplement may be a viable alternative to other muscle-building formulas for those looking to trim down and work on their lean muscle mass. But it is absolutely essential that users combine supplementation with a protein-rich, heart-healthy diet and routine exercise.


  • Readily and legally available when ordered online in the US
  • Clinically-proven to have positive effects on men, young and old alike
  • No significant changes to liver enzymes or prostate-specific antigen when administered daily
  • Can be taken orally as a daily supplement with no need for injections or visits to a doctor
  • Natural peptide with no known contraindications
  • May increase resistance to exercise-related fatigue
  • AR antagonist with a proven influence on human growth hormone
  • Said to be 11 x stronger than Ostarine, a similar SARM


  • May cause tiredness, fatigue or exhaustion
  • May cause decreased libido
  • May suppress testicular hormones

Ligandrol Side Effects

While Ligandrol is considered to be the side effect free version of steroids, it isn’t without possible complications.

Found to be safe at doses of 1 mg daily or less, when taking it in the five to 10 mg per day range may have different results.

At higher levels, users might experience temporary testosterone suppression while taking the supplement. Testosterone levels should return to normal within two to three weeks after cycling off LGD-4033.

Estrogen and liver function is not affected by Ligandrol, so users shouldn’t experience any issues with libido, digestion, or their skin while on the cycle.

Anecdotally, users report losing a small percentage of the weight they gained while taking the supplement once they cycled off of the product.

Proper Dosing

It is always imperative that users stick to recommended dosages when experimenting with supplements, particularly in the case of SARMs which are technically classified as research or investigative chemicals.

A healthy individual considering how to take Ligandrol could use the results of a scientific study that proved the safe