Noopept Review: Nootropic Benefits, Side Effects, and Dosage
Noopept is a nootropic supplement promoted and prescribed in Russia and neighboring countries as a smart drug and cognitive enhancer. It is derived from the racetam family of drugs and shares similar mechanisms of action, but is between 100 to 1000 times more potent than the prototypical racetam drug, piracetam. Animal studies have shown Noopept to be neuroprotective and enhance memory in various tests.
Unusually for a peptide-derived compound, Noopept displays both high oral bioavailability and good blood–brain barrier penetration in rats and human studies have shown promising results, with potential application in the treatment of Alzheimer’s disease. It is also an “immuno-corrector” in mice. It has been found to stimulate the expression of NGF and BDNF in rat hippocampus, the result of which is associated with reduction and prevention of neuronal degeneration.
The release of Brain-Derived Neurotrophic Factor (BDNF) helps keep our neurons healthy and alive, as well as strengthening the growth and differentiation of new neurons and synapses. Noopept stimulates the AMPA and NMDA receptors and their pathways, both of these receptors are glutamatergic receptors which play roles in memory and thought processes.
Noopept is a peptide that can be taken orally, and thus passes readily through the Blood Brain Barrier (BBB). Noopept is of the racetam chemical class that has been shown, according to studies, to be much stronger than Piracetam.
Noopept has the potential of having anxiolytic benefits through the reported stimulation of Dopamine receptors D2 and D3 as well as nicotinic ACh receptors. Noopept also has both an anti-inflammatory benefit, as well as generate antioxidant advantages.
Noopept has been shown to stimulate and promote two proteins involved in generating new neurons as well as preserving and strengthening damaged neurons in the Hippocampus. The growth of new neurons suggests that Noopept, has potentially lasting effects even after administration has been halted.
Using Noopept Safely – Side Effects
By the registered manufactures of Noopept, the substance has been deemed safe in clinical trials. Their drug studies have shown it to be effective and low in toxicity at the recommended dosages. There is limited data to suggest dangerous overdoses can occur however, it is a very potent compound and needs to be treated with care. The likelihood of overdose, whether it be life threatening or not, is higher than with the racetam family.
Overdose will likely lead to unpleasant side effects like headaches, irritability, etc. Below are some of the common side effects of Noopept that are likely to occur at higher dosages.
- Gastrointestinal Problems
These side effects are likely to vary. Always consult a doctor before using Noopept, especially when using other medications or supplements. At this time, there are no records of dangerous drug interactions or side effects with Noopept; however, this does not mean they cannot or will not occur.
Tolerance and withdrawal with Noopept is not serious and should not be a concern. In fact, some animal studies (and anecdotal human reports) have suggested a “snowballing” effect where the beneficial effects of Noopept increase overtime. This does not mean that this is repeated in the human model or that tolerance cannot occur. There does not seem to be a serious physical dependence problem with Noopept and tolerance is most likely to result in loss of beneficial effects that can be eliminated with cycling.
How It Works – the Science Behind Noopept
Noopept is famously quoted as being “1000 times stronger than Piracetam”. This is a true statement in terms of potency because Noopept gets metabolized much more efficiently than the racetam family. This means a much lower dosage is needed to get desired results from the drug. This requires one to be much more careful with their dosing practices.
Noopept’s method of action is similar to the other racetams. Noopept works on the AMPA and NDMA receptor sites and their pathways of function. It also has an affinity with the Acetylcholine system and the ACh receptor sites. Both of these factors contribute to Noopept’s array of nootropic benefits.
Like Aniracetam, Noopept seems to stimulate an anxiolytic response in animal and human models. This is not a guaranteed result and seems to vary widely between subjects. And as with Aniracetam, Noopept seems stimulate Dopamine receptor sites (D2 and D3) as well as the ACh nicotinic receptor sites. Noopept also seems to stimulate certain Serotonin receptors and this may also lead to mood boosting qualities.
Noopept is being investigated as a possible treatment for Alzheimer’s. It is believed by some that it may work beyond the areas of increasing cognition and memory. In lab rats NGF (nerve-growth factor) was increased after administration. This reflects some promise in repairing damaged cells and receptor sites that are commonly seem in Alzheimer’s patients. There is no proof this may be repeated in human models and it is investigated in the pharmacological industry.
In one study, Noopept was shown that Noopept may aid in treating Parkinson’s disease by alleviating amyloid oligomeric cytotoxicity.
One paper presented showed that Noopept’s effective dose was, in comparison to Piracetam, 1000 times lower and also that spectrum of sensation activity (vision and hearing) was greater with Noopept.
Does Noopept “Work” as a Nootropic?
Noopept is often promoted as a natural method of improving cognitive functions. There have been clinical studies suggesting that Noopept may increase memory recall and retention, repair or improve neuron growth in the hippocampus, and have anti-anxiety benefits.
When it comes to improving cognitive abilities, there are still many variables, and these have to be looked at. As a result, it is very hard to determine just how effective Noopept would be for a specific person. It all comes down to their own needs and current cognitive ability as well as lifestyle choices.
Noopept’s Positive Effects and Benefits
Noopept has many positive effects that will make the day-to-day grind of life much easier and manageable. Life as you know it is a constant challenge that, at times, may seem hard to get through. People turn to harmful alternatives like cigarettes, pills, and caffeine to relieve stress.
However, Noopept is a much safer way to relieve stress. It has the added benefit of giving your brain a much needed boost to start a new day in life. Noopept’s effects do not cause physical harm in the same way that drugs and alcohol do, as long as you follow simple directions of dosage.
- Better Overall Cognitive Performance
- Increased Learning Ability
- Enhanced Memory
- Improved Reflexes & Perception
- Advanced Logical Thinking
- Improved Mood (Reduced Anxiety & Depression Symptoms)
What does Noopept feel like?
Casual users have also reported a mild euphoria — not “euphoric” in the sense of feeling a rush of energy, but rather more alert and open to their surroundings. This Longecity post accurately explains the feeling:
For the sake of relation, the effects are somewhat like a low dose ecstasy. Anxiety wafts away. Sensory information is much more clearer. Socializing comes easier.
The world becomes a bit more beautiful. However, it doesn’t have the euphoric properties of ecstasy. I find that it barely alters mood, besides making one more calmer and content.
Patients often feel that they also feel like they have a higher self-esteem when they take noopept. They realized they can complete their daily tasks much more easily than before. Furthermore, verbal communication is also much easier for them due to the increase of self-esteem.
The right Noopept dosage is typically around 10-30 milligrams. How much you should take within that range solely depends on a number of characteristics. First you must take into account how much you weigh. If you weigh less than 140lbs, then I recommend you take only 10mg. If you fall in between 140-200 pounds then I suggest you to take 20mg. For those of you that are over 200lbs then take 30mg. All these figures are per day dosage figures.
Noopept is non-toxic and is very safe to take because of its extremely low doses. You will not experience any negative side effects if you stick to your normal amount of 10-30mg. However, if you go beyond 30mg then you might suffer from some side effects.
Too much Noopept can be a bad thing
Some people think that taking a higher dose will help them more. That is definitely not the case because your body can’t handle higher doses of Noopept. It is too powerful for your body.
In fact, I have a colleague who tried to take 100mg doses at a time. Normally, you will have to take 3 doses a day. Therefore, the first two doses went pretty good for him. However, the third dose began to affect him in a way where he became very emotionless.
The most common side effect that people are experiencing from Noopept is drowsiness. That may not seem like a harmful side effect but there is more. Other side effects include irritation of whole body, sedation, emotional numbness and in worst cases even death. Be very careful and always stick to your preferred dosages.
What should you do if you took a high dose of Noopept?
If you’ve been taking high doses of Noopept, quickly find a quiet, relaxing space and drink lots of water. If symptoms start to go downhill, it’s never too late to see a doctor so don’t hesitate and go right away. The longer you wait then the worst may happen to you. You don’t want to suffer horrible consequences that can be solved if you seek for help.
Noopept is a nootropic that is 100% safe to use if you follow the right Noopept dosages. It’s a strong substance that will enhance your brainpower to further limits! However, too much of it at a time will lead to serious problems that you definitely don’t want to experience. Always stick to your own dosages depending on how much you weigh. If you take too much, then immediately seek help from a doctor because it will help prevent any further serious side effects.
Noopept is available in both tablet and powder form.
Noopept Experiences/User Reports
A Redditor’s Noopept Experience
A Redditor decided to try Noopept and shared the experience on r/nootropics. The Redditor had been using Noopept for year prior to the experiment, and reported zero negative side effects when taking 10-30 milligrams of the smart drug three times a day.
He never took more than 3 times a day or take over 30 milligrams at a time. The result: it definitely helped him stay focused and motivated to start work each and every day since he works 6 days a week at the office. He feels energized in the morning and no longer needs to rely on caffeine.
The first time he took Noopept, he got exactly the results he wanted: clear-headed, sharp, and focused.
NOTE: Severe Diminishing Returns
After that, he could get the same result only ~10% of the time, with the other 90% being brain fog and a complete lack of focus. He started with 10mg twice a day and then experimented down to 8mg and up to 15.
The 15 mg twice a day made me feel mentally handicapped. The experiment was conducted tried with and without choline.
My personal note: I believe this is somewhat of an extreme case, but I can related to the Redditor’s experience. I have dosed > 80mg of Noopept for weeks with little effect; however, it absolutely does have diminishing returns if used consistently for more than a month.
Gwern Branwen’s Self-Quantification
Related to the famous -racetams but reportedly better (and much less bulky), Noopept is one of the many obscure Russian nootropics. (Further reading: Google Scholar, Examine.com, Reddit, Longecity, Bluelight.ru.)
Its advantages seem to be that it’s far more compact than piracetam and doesn’t taste awful, so it’s easier to store and consume; doesn’t have the cloud hanging over it that piracetam does due to the FDA letters, so it’s easy to purchase through normal channels; is cheap on a per-dose basis; and it has fans claiming it is better than piracetam.
A Redditor ordered some Russian brand Noopept, but finding it was unpleasant & not working for him, gave the left-over half to Gwern.
He took 2 of the 25 10mg pills on successive days on top of my usual caffeine+piracetam stack, and didn’t notice anything; in particular, he didn’t find it unpleasant like the Redditor did.
He thought to experiment, and puting the 23 remaining pills into gel capsules with brown rice as filling, made ~30 placebo capsules. He didn’t want to spend the time it would take to n-back every day, so he decided to look for effects on daily mood/productivity self-rating.
His hope was that Noopept would add a little on average above and beyond his existing practices like caffeine+piracetam (yes, Noopept may be as good as piracetam).
For Gwern, 10mg doses seem to be on the low side for Noopept users, weakening the effect. But on the other hand, if he were to take 2 capsules at a time, then he’d halve the sample size.
Gwern was not certain how important the results are – partly because he didn’t notice anything bad from taking Noopept. He notes that any negative effect would be subtle: people seem to think that 10mg is too small for an ingested rather than sublingual dose and and that Noopept’s effects tend to manifest with consistent use, with less of an acute effect.
Gwern’s Follow-up: Compensating for Ingested Doses
In using powder, there are two opposite considerations: Russian Noopept is reportedly the best, so Gwern expected any online-sourced Noopept to be weaker or impure or inferior somehow and the effect size smaller than in the pilot experiment. He guessed that, by sourcing quality Noopept & using powder, he could double the dose to 20mg (to compensate for ingestion rather than sublingual dosing) and so the effect size larger than in the pilot experiment.
Noopept appears to be safe to stack with other racetams or nootropics. There are limited reports of serious drug interactions but due diligence is advised when combining substances and is done at the risk of the user. Common stacks with Noopept are with a choline source like, Alpha GPC as this can often help relieve common side effects. Other racetam combinations are also common, but Noopept is usually taken alone; it’s strong enough by itself and relatively expensive compared to the racetams.
My Personal Noopept Powder Comparison
It may be challenge to find the right Noopept powder that is suitable for you. Since there are so many different kinds available on internet, an immediate decision isn’t possible. Noopept is such a powerful substance so you must be very careful to find the right one for you.
Therefore, to make things easier for you, I will provide in full detail a comparison of two commonly used noopept powders. Furthermore, I will list how they are different as well. Nonetheless, I hope that you in the end will reach a decision upon the choosing the right noopept for you.
The Two Noopept Powders that I will compare and contrast:
How are they similar?
First and foremost, these two products are similar in terms of the functions of a Noopept powder. They both promise that it will enhance your memory. If you can’t recall some things that happened recently then these are great options to help polish your memory.
Furthermore, both powders are currently known as a potential treatment to the horrors of Alzheimer’s disease. As of now, there is not treatment for this horrible disease. But it is known that may prevent that disease from occurring if you keep your brain strong and healthy.
Both powders will improve your concentration. Working over 40 hours a week especially if you are doing a lot of manual labor is stressful. Sooner or later, you will begin to experience a loss of concentration due to the lack of sleep or rest. Thankfully, these powders will keep you concentrated and focused to motivate you to continue to work hard to get the job done.
Lastly, both powders are known to keep your brain healthy and functioning properly. The last thing you’ll need an unhealthy brain. The brain is your most vital part of your human body. An unhealthy brain will lead to many diseases like Alzheimer’s like I mentioned before. So these powders are an essential option to keep your brain healthy.
How are they different?
The first difference between these two products is the price. The Noopept powder from Absorb Your Health is affordably priced at $20 for 10g, whereas the powder from Powder City is only $12.25 for 10g.
Note: Powder City’s low price is not reflective of their quality. As many users on r/nootropics have noted in the past few months (as of May 2016), they have excellent quality and customer service.
Final note: how to measure Noopept doses
If you have decided on a specific Noopept powder, it is extremely important you know how to measure your own dosage. I strongly recommending investing in a quality scale to measure efficient doses. I use Norpro 3080 Mini Measuring Spoons as well.
Depending on your weight, dosages should be around 10-30mg. Anything over 200mg will have side effects that may be harmful such as irritation of your whole body and sedation.